Transportation has a strong influence on the spatial structure at the local, regional, and global levels. Contemporary economic processes have been accompanied by a significant increase in mobility and higher levels of accessibility. Such conditions are closely related to the development of transportation networks, both in capacity and spatial extent. It also underlines the importance of specific dimensions, such as nodes, locations, networks, and interactions. The impacts of transport on the spatial structure became multiscalar. Transportation systems are composed of a complex set of relationships between the demand, the locations they service, and the networks that support movements. The introduction of information technologies is changing mobility and its relations with geography since it can support, modify, substitute, or expand transportation activities.